BIOINFORMATICS ANALYSIS OF MICRORNAS ASSOCIATED WITH KRAS AND EGFR MUTATION IN COLORECTAL CANCER (MICRORNAS PREDICTION IN COLON CANCER)

Authors

  • Namphon Klaewkla Biomedical Sciences Research Unit, College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand
  • Surasak Wanram Biomedical Sciences Research Unit, College of Medicine and Public Health. Ubon Ratchathani University, Ubon Ratchathani, Thailand

Keywords:

MicroRNAs (miRNAs), Prediction, KRAS mutation, EGFR mutation, Colorectal Cancer

Abstract

Colorectal cancer (CRC) is the third most common cancer in the world. Epigenetic regulation by non-coding RNAs or microRNAs (miRNAs) plays a role in cancer development and progression. Mutated genes such as KRAS and EGFR are associated with CRC carcinogenesis and play an important role in controlling the cellular process. The specific expressions of miRNAs serving as biomarkers for early diagnosis or prognosis of CRC are still unclear. The purpose of this

study[3] was to identify potential miRNAs specific to KRAS and EGFR mutation using bioinformatics tools for prediction. The candidate miRNAs associated with interested target genes can be predicted. Selection of the candidate miRNAs should be validated and required for further development as biomarkers for colon cancer diagnosis and treatment.

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Published

2023-12-01

How to Cite

Klaewkla, N., & Wanram, S. (2023). BIOINFORMATICS ANALYSIS OF MICRORNAS ASSOCIATED WITH KRAS AND EGFR MUTATION IN COLORECTAL CANCER (MICRORNAS PREDICTION IN COLON CANCER). Timor-Leste Journal of Medical Science, 1(1), pp.53–67. Retrieved from http://jmedicalsciences.tl/index.php/TLJMS/article/view/3

Issue

Vol. 1 No. 1 (2023): Contemporary Problems, Challenges and Solutions for the Health Sciences

Section

Articles

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